Adjuvant radiotherapy after radical cystectomy for patients with muscle invasive bladder cancer: a phase II trial
Identifieur interne : 000801 ( Main/Exploration ); précédent : 000800; suivant : 000802Adjuvant radiotherapy after radical cystectomy for patients with muscle invasive bladder cancer: a phase II trial
Auteurs : Valérie Fonteyne [Belgique] ; Piet Dirix [Belgique] ; Sara Junius [Belgique] ; Elke Rammant [Belgique] ; Piet Ost [Belgique] ; Gert De Meerleer [Belgique] ; Martijn Swimberghe [Belgique] ; Karel Decaestecker [Belgique]Source :
- BMC Cancer [ 1471-2407 ] ; 2017.
Abstract
Neo-adjuvant chemotherapy followed by radical cystectomy with extended pelvic lymph node dissection is considered to be the treatment of choice for patients with muscle invasive bladder cancer (MIBC). Despite this aggressive treatment the outcome is poor and ultimately, 30% of the patients with ≥pT3 tumors develop a pelvic recurrence. We hypothesize that postoperative adjuvant external beam radiotherapy (EBRT) might prevent local and lymph node recurrence and improve disease free- and overall survival as loco-regional recurrence is linked to the development of distant metastasis.
We plan to perform a multicentric prospective phase two study including 76 patients. Eligible patients are patients with MIBC, treated with radical cystectomy and presenting with ≥1 of the following characteristics: Pathological (p)T3 stage + presence of lymphovascular invasion on pathological examination pT4 stage <10 lymph nodes removed positive lymph nodes positive surgical margins
Patients will have a 18F–FDG PET-CT to rule out the presence of distant metastasis prior to EBRT. A median dose of 50 Gy in 25 fractions is prescribed to the pelvic lymph node regions with inclusion of the operative bladder bed in case of a positive surgical margin. Patients with suspected lymph nodes on PET- CT can still be included in the trial, but a simultaneous integrated boost to 74Gy to the positive lymph nodes will be delivered. Blood and urine samples will be collected on day-1 and last day of EBRT for evaluation of biomarkers. The primary endpoint is evaluation of acute ≥Grade 3 intestinal or grade 4 urinary toxicity, in case of a neo-bladder reconstruction, within 12 weeks after EBRT. Secondary endpoints are: assessment of QOL, late RTOG toxicity, local control, disease free survival and overall survival. Biomarkers in urine and blood will be correlated with secondary survival endpoints.
This is a prospective phase 2 trial re-assessing the feasibility of adjuvant radiotherapy in high-risk MIBC.
The Ethics committee of the Ghent University Hospital (EC2014/0630) approved this study on 31/07/2014.
Trial registration on Clinicaltrials.gov (
Url:
DOI: 10.1186/s12885-017-3302-9
PubMed: 28464906
PubMed Central: 5414216
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000C44
- to stream Pmc, to step Curation: 000C43
- to stream Pmc, to step Checkpoint: 000404
- to stream Ncbi, to step Merge: 009029
- to stream Ncbi, to step Curation: 009029
- to stream Ncbi, to step Checkpoint: 009029
- to stream Main, to step Merge: 000802
- to stream Main, to step Curation: 000801
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Adjuvant radiotherapy after radical cystectomy for patients with muscle invasive bladder cancer: a phase II trial</title><author><name sortKey="Fonteyne, Valerie" sort="Fonteyne, Valerie" uniqKey="Fonteyne V" first="Valérie" last="Fonteyne">Valérie Fonteyne</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0626 3303</institution-id><institution-id institution-id-type="GRID">grid.410566.0</institution-id><institution>Department of Radiation-Oncology,</institution><institution>Ghent University Hospital,</institution></institution-wrap>De Pintelaan 185, Ghent, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>De Pintelaan 185, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Dirix, Piet" sort="Dirix, Piet" uniqKey="Dirix P" first="Piet" last="Dirix">Piet Dirix</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Department of Radiation-Oncology, Iridium Cancer Network, Ghent, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Radiation-Oncology, Iridium Cancer Network, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Junius, Sara" sort="Junius, Sara" uniqKey="Junius S" first="Sara" last="Junius">Sara Junius</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Radiation-Oncology CH-M/AMPR, Mouscron, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Radiation-Oncology CH-M/AMPR, Mouscron</wicri:regionArea><wicri:noRegion>Mouscron</wicri:noRegion></affiliation></author><author><name sortKey="Rammant, Elke" sort="Rammant, Elke" uniqKey="Rammant E" first="Elke" last="Rammant">Elke Rammant</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0626 3303</institution-id><institution-id institution-id-type="GRID">grid.410566.0</institution-id><institution>Department of Radiation-Oncology,</institution><institution>Ghent University Hospital,</institution></institution-wrap>De Pintelaan 185, Ghent, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>De Pintelaan 185, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Ost, Piet" sort="Ost, Piet" uniqKey="Ost P" first="Piet" last="Ost">Piet Ost</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0626 3303</institution-id><institution-id institution-id-type="GRID">grid.410566.0</institution-id><institution>Department of Radiation-Oncology,</institution><institution>Ghent University Hospital,</institution></institution-wrap>De Pintelaan 185, Ghent, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>De Pintelaan 185, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="De Meerleer, Gert" sort="De Meerleer, Gert" uniqKey="De Meerleer G" first="Gert" last="De Meerleer">Gert De Meerleer</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2069 7798</institution-id><institution-id institution-id-type="GRID">grid.5342.0</institution-id><institution>Department of Radiotherapy and Experimental Cancer Research,</institution><institution>Ghent University,</institution></institution-wrap>Ghent, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Ghent</wicri:regionArea></affiliation></author><author><name sortKey="Swimberghe, Martijn" sort="Swimberghe, Martijn" uniqKey="Swimberghe M" first="Martijn" last="Swimberghe">Martijn Swimberghe</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0626 3303</institution-id><institution-id institution-id-type="GRID">grid.410566.0</institution-id><institution>Department of Radiation-Oncology,</institution><institution>Ghent University Hospital,</institution></institution-wrap>De Pintelaan 185, Ghent, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>De Pintelaan 185, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Decaestecker, Karel" sort="Decaestecker, Karel" uniqKey="Decaestecker K" first="Karel" last="Decaestecker">Karel Decaestecker</name><affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0626 3303</institution-id><institution-id institution-id-type="GRID">grid.410566.0</institution-id><institution>Department of Urology,</institution><institution>Ghent University Hospital,</institution></institution-wrap>Ghent, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Ghent</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28464906</idno><idno type="pmc">5414216</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414216</idno><idno type="RBID">PMC:5414216</idno><idno type="doi">10.1186/s12885-017-3302-9</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000C44</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000C44</idno><idno type="wicri:Area/Pmc/Curation">000C43</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000C43</idno><idno type="wicri:Area/Pmc/Checkpoint">000404</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000404</idno><idno type="wicri:Area/Ncbi/Merge">009029</idno><idno type="wicri:Area/Ncbi/Curation">009029</idno><idno type="wicri:Area/Ncbi/Checkpoint">009029</idno><idno type="wicri:Area/Main/Merge">000802</idno><idno type="wicri:Area/Main/Curation">000801</idno><idno type="wicri:Area/Main/Exploration">000801</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Adjuvant radiotherapy after radical cystectomy for patients with muscle invasive bladder cancer: a phase II trial</title><author><name sortKey="Fonteyne, Valerie" sort="Fonteyne, Valerie" uniqKey="Fonteyne V" first="Valérie" last="Fonteyne">Valérie Fonteyne</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0626 3303</institution-id><institution-id institution-id-type="GRID">grid.410566.0</institution-id><institution>Department of Radiation-Oncology,</institution><institution>Ghent University Hospital,</institution></institution-wrap>De Pintelaan 185, Ghent, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>De Pintelaan 185, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Dirix, Piet" sort="Dirix, Piet" uniqKey="Dirix P" first="Piet" last="Dirix">Piet Dirix</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Department of Radiation-Oncology, Iridium Cancer Network, Ghent, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Radiation-Oncology, Iridium Cancer Network, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Junius, Sara" sort="Junius, Sara" uniqKey="Junius S" first="Sara" last="Junius">Sara Junius</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Radiation-Oncology CH-M/AMPR, Mouscron, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Radiation-Oncology CH-M/AMPR, Mouscron</wicri:regionArea><wicri:noRegion>Mouscron</wicri:noRegion></affiliation></author><author><name sortKey="Rammant, Elke" sort="Rammant, Elke" uniqKey="Rammant E" first="Elke" last="Rammant">Elke Rammant</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0626 3303</institution-id><institution-id institution-id-type="GRID">grid.410566.0</institution-id><institution>Department of Radiation-Oncology,</institution><institution>Ghent University Hospital,</institution></institution-wrap>De Pintelaan 185, Ghent, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>De Pintelaan 185, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Ost, Piet" sort="Ost, Piet" uniqKey="Ost P" first="Piet" last="Ost">Piet Ost</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0626 3303</institution-id><institution-id institution-id-type="GRID">grid.410566.0</institution-id><institution>Department of Radiation-Oncology,</institution><institution>Ghent University Hospital,</institution></institution-wrap>De Pintelaan 185, Ghent, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>De Pintelaan 185, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="De Meerleer, Gert" sort="De Meerleer, Gert" uniqKey="De Meerleer G" first="Gert" last="De Meerleer">Gert De Meerleer</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2069 7798</institution-id><institution-id institution-id-type="GRID">grid.5342.0</institution-id><institution>Department of Radiotherapy and Experimental Cancer Research,</institution><institution>Ghent University,</institution></institution-wrap>Ghent, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Ghent</wicri:regionArea></affiliation></author><author><name sortKey="Swimberghe, Martijn" sort="Swimberghe, Martijn" uniqKey="Swimberghe M" first="Martijn" last="Swimberghe">Martijn Swimberghe</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0626 3303</institution-id><institution-id institution-id-type="GRID">grid.410566.0</institution-id><institution>Department of Radiation-Oncology,</institution><institution>Ghent University Hospital,</institution></institution-wrap>De Pintelaan 185, Ghent, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>De Pintelaan 185, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Decaestecker, Karel" sort="Decaestecker, Karel" uniqKey="Decaestecker K" first="Karel" last="Decaestecker">Karel Decaestecker</name><affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0626 3303</institution-id><institution-id institution-id-type="GRID">grid.410566.0</institution-id><institution>Department of Urology,</institution><institution>Ghent University Hospital,</institution></institution-wrap>Ghent, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Ghent</wicri:regionArea></affiliation></author></analytic><series><title level="j">BMC Cancer</title><idno type="eISSN">1471-2407</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Neo-adjuvant chemotherapy followed by radical cystectomy with extended pelvic lymph node dissection is considered to be the treatment of choice for patients with muscle invasive bladder cancer (MIBC). Despite this aggressive treatment the outcome is poor and ultimately, 30% of the patients with ≥pT3 tumors develop a pelvic recurrence. We hypothesize that postoperative adjuvant external beam radiotherapy (EBRT) might prevent local and lymph node recurrence and improve disease free- and overall survival as loco-regional recurrence is linked to the development of distant metastasis.</p></sec><sec><title>Methods</title><p>We plan to perform a multicentric prospective phase two study including 76 patients. Eligible patients are patients with MIBC, treated with radical cystectomy and presenting with ≥1 of the following characteristics:<list list-type="bullet"><list-item><p>Pathological (p)T3 stage + presence of lymphovascular invasion on pathological examination</p></list-item><list-item><p>pT4 stage</p></list-item><list-item><p><10 lymph nodes removed</p></list-item><list-item><p>positive lymph nodes</p></list-item><list-item><p>positive surgical margins</p></list-item></list></p><p>Patients will have a <sup>18</sup>F–FDG PET-CT to rule out the presence of distant metastasis prior to EBRT. A median dose of 50 Gy in 25 fractions is prescribed to the pelvic lymph node regions with inclusion of the operative bladder bed in case of a positive surgical margin. Patients with suspected lymph nodes on PET- CT can still be included in the trial, but a simultaneous integrated boost to 74Gy to the positive lymph nodes will be delivered. Blood and urine samples will be collected on day-1 and last day of EBRT for evaluation of biomarkers. The primary endpoint is evaluation of acute ≥Grade 3 intestinal or grade 4 urinary toxicity, in case of a neo-bladder reconstruction, within 12 weeks after EBRT. Secondary endpoints are: assessment of QOL, late RTOG toxicity, local control, disease free survival and overall survival. Biomarkers in urine and blood will be correlated with secondary survival endpoints.</p></sec><sec><title>Discussion</title><p>This is a prospective phase 2 trial re-assessing the feasibility of adjuvant radiotherapy in high-risk MIBC.</p></sec><sec><title>Trial registration</title><p>The Ethics committee of the Ghent University Hospital (EC2014/0630) approved this study on 31/07/2014.</p><p>Trial registration on Clinicaltrials.gov (<ext-link ext-link-type="uri" xlink:href="https://clinicaltrials.gov/ct2/show/NCT02397434">NCT02397434</ext-link>) on November 19, 2014.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Sebastian Antoni, Jf" uniqKey="Sebastian Antoni J">JF Sebastian Antoni</name></author><author><name sortKey="Soerjomataram, I" uniqKey="Soerjomataram I">I Soerjomataram</name></author><author><name sortKey="Znaor, A" uniqKey="Znaor A">A Znaor</name></author><author><name sortKey="Jemal, A" uniqKey="Jemal A">A Jemal</name></author><author><name sortKey="Bray, F" uniqKey="Bray F">F Bray</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Zehdner, P" uniqKey="Zehdner P">P Zehdner</name></author><author><name sortKey="Studer, Ue" uniqKey="Studer U">UE Studer</name></author><author><name sortKey="Skineer, Ec" uniqKey="Skineer E">EC Skineer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grossman, Hb" uniqKey="Grossman H">HB Grossman</name></author><author><name sortKey="Natale, Rb" uniqKey="Natale R">RB Natale</name></author><author><name sortKey="Tangen, Cm" uniqKey="Tangen C">CM Tangen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shariat, Sf" uniqKey="Shariat S">SF Shariat</name></author><author><name sortKey="Karakiewicz, Pi" uniqKey="Karakiewicz P">PI Karakiewicz</name></author><author><name sortKey="Palapattu, Gs" uniqKey="Palapattu G">GS Palapattu</name></author><author><name sortKey="Lotan, Y" uniqKey="Lotan Y">Y Lotan</name></author><author><name sortKey="Rogers, Cg" uniqKey="Rogers C">CG Rogers</name></author><author><name sortKey="Amiel, Ge" uniqKey="Amiel G">GE Amiel</name></author><author><name sortKey="Vazina, A" uniqKey="Vazina A">A Vazina</name></author><author><name sortKey="Gupta, A" uniqKey="Gupta A">A Gupta</name></author><author><name sortKey="Bastian, Pj" uniqKey="Bastian P">PJ Bastian</name></author><author><name sortKey="Sagalowsky, Ai" uniqKey="Sagalowsky A">AI Sagalowsky</name></author><author><name sortKey="Schoenberg, Mp" uniqKey="Schoenberg M">MP Schoenberg</name></author><author><name sortKey="Lerner, Sp" uniqKey="Lerner S">SP Lerner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raza, Sj" uniqKey="Raza S">SJ Raza</name></author><author><name sortKey="Wilson, T" uniqKey="Wilson T">T Wilson</name></author><author><name sortKey="Peabody, Jo" uniqKey="Peabody J">JO Peabody</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baumann, Bc" uniqKey="Baumann B">BC Baumann</name></author><author><name sortKey="Guzzo, T" uniqKey="Guzzo T">T Guzzo</name></author><author><name sortKey="He, J" uniqKey="He J">J He</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Herr, Hw" uniqKey="Herr H">HW Herr</name></author><author><name sortKey="Faulkner, Jr" uniqKey="Faulkner J">JR Faulkner</name></author><author><name sortKey="Grossman, Hb" uniqKey="Grossman H">HB Grossman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Christodouleas, Jp" uniqKey="Christodouleas J">JP Christodouleas</name></author><author><name sortKey="Baumann, Bc" uniqKey="Baumann B">BC Baumann</name></author><author><name sortKey="He, J" uniqKey="He J">J He</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leow, Jj" uniqKey="Leow J">JJ Leow</name></author><author><name sortKey="Martin Doyle, W" uniqKey="Martin Doyle W">W Martin-Doyle</name></author><author><name sortKey="Fay, Ap" uniqKey="Fay A">AP Fay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sternberg, Cn" uniqKey="Sternberg C">CN Sternberg</name></author><author><name sortKey="Sylvester, R" uniqKey="Sylvester R">R Sylvester</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dovedi, S" uniqKey="Dovedi S">S Dovedi</name></author><author><name sortKey="Adlard, Al" uniqKey="Adlard A">AL Adlard</name></author><author><name sortKey="Lipowska Bhalla, G" uniqKey="Lipowska Bhalla G">G Lipowska-Bhalla</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reddy, Av" uniqKey="Reddy A">AV Reddy</name></author><author><name sortKey="Pariser, Jj" uniqKey="Pariser J">JJ Pariser</name></author><author><name sortKey="Pearce, Sm" uniqKey="Pearce S">SM Pearce</name></author><author><name sortKey="Weichselbaum, Rr" uniqKey="Weichselbaum R">RR Weichselbaum</name></author><author><name sortKey="Smith, Nd" uniqKey="Smith N">ND Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ploeg, M" uniqKey="Ploeg M">M Ploeg</name></author><author><name sortKey="Kums, Ac" uniqKey="Kums A">AC Kums</name></author><author><name sortKey="Aben, Kk" uniqKey="Aben K">KK Aben</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pollack, A" uniqKey="Pollack A">A Pollack</name></author><author><name sortKey="Zagars, Gk" uniqKey="Zagars G">GK Zagars</name></author><author><name sortKey="Dinney, Cp" uniqKey="Dinney C">CP Dinney</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ide, H" uniqKey="Ide H">H Ide</name></author><author><name sortKey="Kikuchi, E" uniqKey="Kikuchi E">E Kikuchi</name></author><author><name sortKey="Miyajima, A" uniqKey="Miyajima A">A Miyajima</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huncharek, M" uniqKey="Huncharek M">M Huncharek</name></author><author><name sortKey="Muscat, J" uniqKey="Muscat J">J Muscat</name></author><author><name sortKey="Geschwind, Jf" uniqKey="Geschwind J">JF Geschwind</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zaghloul, Ms" uniqKey="Zaghloul M">MS Zaghloul</name></author><author><name sortKey="Awwad, Hk" uniqKey="Awwad H">HK Awwad</name></author><author><name sortKey="Omar, S" uniqKey="Omar S">S Omar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zaghloul, Ms" uniqKey="Zaghloul M">MS Zaghloul</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reisinger, S" uniqKey="Reisinger S">S Reisinger</name></author><author><name sortKey="Mohiuddin, M" uniqKey="Mohiuddin M">M Mohiuddin</name></author><author><name sortKey="Mulholland, S" uniqKey="Mulholland S">S Mulholland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang Chesebro, A" uniqKey="Wang Chesebro A">A Wang-Chesebro</name></author><author><name sortKey="Xia, P" uniqKey="Xia P">P Xia</name></author><author><name sortKey="Coleman, J" uniqKey="Coleman J">J Coleman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fonteyne, V" uniqKey="Fonteyne V">V Fonteyne</name></author><author><name sortKey="Lumen, N" uniqKey="Lumen N">N Lumen</name></author><author><name sortKey="Ost, P" uniqKey="Ost P">P Ost</name></author><author><name sortKey="Van Praet, C" uniqKey="Van Praet C">C Van Praet</name></author><author><name sortKey="Vandecasteele, K" uniqKey="Vandecasteele K">K Vandecasteele</name></author><author><name sortKey="De Gersem, W" uniqKey="De Gersem W">W De Gersem</name></author><author><name sortKey="Villeirs, G" uniqKey="Villeirs G">G Villeirs</name></author><author><name sortKey="De Neve, W" uniqKey="De Neve W">W De Neve</name></author><author><name sortKey="Decaestecker, K" uniqKey="Decaestecker K">K Decaestecker</name></author><author><name sortKey="De Meerleer, G" uniqKey="De Meerleer G">G De Meerleer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vandecasteele, K" uniqKey="Vandecasteele K">K Vandecasteele</name></author><author><name sortKey="De Neve, W" uniqKey="De Neve W">W De Neve</name></author><author><name sortKey="De Gersem, W" uniqKey="De Gersem W">W De Gersem</name></author><author><name sortKey="Delrue, L" uniqKey="Delrue L">L Delrue</name></author><author><name sortKey="Paelinck, L" uniqKey="Paelinck L">L Paelinck</name></author><author><name sortKey="Makar, A" uniqKey="Makar A">A Makar</name></author><author><name sortKey="Fonteyne, V" uniqKey="Fonteyne V">V Fonteyne</name></author><author><name sortKey="De Wagter, C" uniqKey="De Wagter C">C De Wagter</name></author><author><name sortKey="Villeirs, G" uniqKey="Villeirs G">G Villeirs</name></author><author><name sortKey="De Meerleer, G" uniqKey="De Meerleer G">G De Meerleer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baumann, Bg" uniqKey="Baumann B">BG Baumann</name></author><author><name sortKey="Guzzo, Tj" uniqKey="Guzzo T">TJ Guzzo</name></author><author><name sortKey="He, J" uniqKey="He J">J He</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Esse, J" uniqKey="Van Esse J">J van Esse</name></author><author><name sortKey="Grosse, J" uniqKey="Grosse J">J Grosse</name></author><author><name sortKey="Pfister, Dj" uniqKey="Pfister D">DJ Pfister</name></author><author><name sortKey="Epplen, R" uniqKey="Epplen R">R Epplen</name></author><author><name sortKey="Heidenreich, A" uniqKey="Heidenreich A">A Heidenreich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alongi, P" uniqKey="Alongi P">P Alongi</name></author><author><name sortKey="Caobelli, F" uniqKey="Caobelli F">F Caobelli</name></author><author><name sortKey="Gentile, R" uniqKey="Gentile R">R Gentile</name></author><author><name sortKey="Stefano, A" uniqKey="Stefano A">A Stefano</name></author><author><name sortKey="Russo, G" uniqKey="Russo G">G Russo</name></author><author><name sortKey="Albano, D" uniqKey="Albano D">D Albano</name></author><author><name sortKey="Baldari, S" uniqKey="Baldari S">S Baldari</name></author><author><name sortKey="Gilardi, Mc" uniqKey="Gilardi M">MC Gilardi</name></author><author><name sortKey="Midiri, M" uniqKey="Midiri M">M Midiri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cox, Jd" uniqKey="Cox J">JD Cox</name></author><author><name sortKey="Stetz, J" uniqKey="Stetz J">J Stetz</name></author><author><name sortKey="Pajak, Tf" uniqKey="Pajak T">TF Pajak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Trotti, A" uniqKey="Trotti A">A Trotti</name></author><author><name sortKey="Colevas, D" uniqKey="Colevas D">D Colevas</name></author><author><name sortKey="Setser, A" uniqKey="Setser A">A Setser</name></author><author><name sortKey="Rusch, V" uniqKey="Rusch V">V Rusch</name></author><author><name sortKey="Jaques, D" uniqKey="Jaques D">D Jaques</name></author><author><name sortKey="Budach, V" uniqKey="Budach V">V Budach</name></author><author><name sortKey="Langer, C" uniqKey="Langer C">C Langer</name></author><author><name sortKey="Murphy, B" uniqKey="Murphy B">B Murphy</name></author><author><name sortKey="Cumberlin, R" uniqKey="Cumberlin R">R Cumberlin</name></author><author><name sortKey="Coleman, Cn" uniqKey="Coleman C">CN Coleman</name></author><author><name sortKey="Rubin, P" uniqKey="Rubin P">P Rubin</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Rosen, Rc" uniqKey="Rosen R">RC Rosen</name></author><author><name sortKey="Riley, A" uniqKey="Riley A">A Riley</name></author><author><name sortKey="Wagner, G" uniqKey="Wagner G">G Wagner</name></author><author><name sortKey="Osterloh, Ih" uniqKey="Osterloh I">IH Osterloh</name></author><author><name sortKey="Kirkpatrick, J" uniqKey="Kirkpatrick J">J Kirkpatrick</name></author><author><name sortKey="Mishra, A" uniqKey="Mishra A">A Mishra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ter Kuile, Mm" uniqKey="Ter Kuile M">MM Ter Kuile</name></author><author><name sortKey="Brauer, M" uniqKey="Brauer M">M Brauer</name></author><author><name sortKey="Laan, E" uniqKey="Laan E">E Laan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barry, Mj" uniqKey="Barry M">MJ Barry</name></author><author><name sortKey="Fowler, Fj" uniqKey="Fowler F">FJ Fowler</name></author><author><name sortKey="O Eary, Mp" uniqKey="O Eary M">MP O’Leary</name></author><author><name sortKey="Bruskewitz, Rc" uniqKey="Bruskewitz R">RC Bruskewitz</name></author><author><name sortKey="Holtgrewe, Hl" uniqKey="Holtgrewe H">HL Holtgrewe</name></author><author><name sortKey="Mebust, Wk" uniqKey="Mebust W">WK Mebust</name></author><author><name sortKey="Cockett, At" uniqKey="Cockett A">AT Cockett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Avery, K" uniqKey="Avery K">K Avery</name></author><author><name sortKey="Donovan, J" uniqKey="Donovan J">J Donovan</name></author><author><name sortKey="Peters, Tj" uniqKey="Peters T">TJ Peters</name></author><author><name sortKey="Shaw, C" uniqKey="Shaw C">C Shaw</name></author><author><name sortKey="Gotoh, M" uniqKey="Gotoh M">M Gotoh</name></author><author><name sortKey="Abrama, P" uniqKey="Abrama P">P ABrama</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pos, Fj" uniqKey="Pos F">FJ Pos</name></author><author><name sortKey="Hart, G" uniqKey="Hart G">G Hart</name></author><author><name sortKey="Schneider, C" uniqKey="Schneider C">C Schneider</name></author><author><name sortKey="Sminia, P" uniqKey="Sminia P">P Sminia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sargos, P" uniqKey="Sargos P">P Sargos</name></author><author><name sortKey="Baumann, Bc" uniqKey="Baumann B">BC Baumann</name></author><author><name sortKey="Eapen, Lj" uniqKey="Eapen L">LJ Eapen</name></author><author><name sortKey="Bahl, A" uniqKey="Bahl A">A Bahl</name></author><author><name sortKey="Murthy, V" uniqKey="Murthy V">V Murthy</name></author><author><name sortKey="Roubaud, G" uniqKey="Roubaud G">G Roubaud</name></author><author><name sortKey="Orre, M" uniqKey="Orre M">M Orré</name></author><author><name sortKey="Efstathiou, Ja" uniqKey="Efstathiou J">JA Efstathiou</name></author><author><name sortKey="Shariat, S" uniqKey="Shariat S">S Shariat</name></author><author><name sortKey="Larre, S" uniqKey="Larre S">S Larré</name></author><author><name sortKey="Richaus, P" uniqKey="Richaus P">P Richaus</name></author><author><name sortKey="Christodouleas, Jp" uniqKey="Christodouleas J">JP Christodouleas</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Belgique</li></country></list><tree><country name="Belgique"><noRegion><name sortKey="Fonteyne, Valerie" sort="Fonteyne, Valerie" uniqKey="Fonteyne V" first="Valérie" last="Fonteyne">Valérie Fonteyne</name></noRegion><name sortKey="De Meerleer, Gert" sort="De Meerleer, Gert" uniqKey="De Meerleer G" first="Gert" last="De Meerleer">Gert De Meerleer</name><name sortKey="Decaestecker, Karel" sort="Decaestecker, Karel" uniqKey="Decaestecker K" first="Karel" last="Decaestecker">Karel Decaestecker</name><name sortKey="Dirix, Piet" sort="Dirix, Piet" uniqKey="Dirix P" first="Piet" last="Dirix">Piet Dirix</name><name sortKey="Junius, Sara" sort="Junius, Sara" uniqKey="Junius S" first="Sara" last="Junius">Sara Junius</name><name sortKey="Ost, Piet" sort="Ost, Piet" uniqKey="Ost P" first="Piet" last="Ost">Piet Ost</name><name sortKey="Rammant, Elke" sort="Rammant, Elke" uniqKey="Rammant E" first="Elke" last="Rammant">Elke Rammant</name><name sortKey="Swimberghe, Martijn" sort="Swimberghe, Martijn" uniqKey="Swimberghe M" first="Martijn" last="Swimberghe">Martijn Swimberghe</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000801 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000801 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:5414216
|texte= Adjuvant radiotherapy after radical cystectomy for patients with muscle invasive bladder cancer: a phase II trial
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:28464906" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |